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Preheat your oven to 180°C.
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In a large bowl, combine the beef mince, salt, pepper, dried oregano, onion powder, and garlic powder. Mix well until evenly combined.
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Spread a layer of Napoletana sauce over the base of a baking dish. Top with a layer of lasagna sheets.
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Sprinkle a portion of the raw mince mixture evenly over the pasta sheets, followed by more Napoletana sauce and a handful of grated cheese.
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Repeat the layers. Lasagna sheets, raw mince mixture, sauce, and cheese, until all ingredients are used, finishing with a final layer of sauce and cheese on top.
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Cover with foil and bake for 35 minutes. Remove the foil and bake for a further 10 minutes, or until the top is golden and bubbling and the pasta is tender.
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Rest for 5-10 minutes before slicing and serving.